3 Proteins to Minimize Heart Attack Damage

THE ESSENTIAL

  • According to Santé Publique France, 2.3% of the French adult population in France suffer from heart failure.
  • According to health insurance companies, between 400,000 and 700,000 people suffer from heart failure without even knowing it.

About 80,000 people suffer a heart attack –also called a heart attack– every year in France, acc Health insurance. This cardiac event can be defined as the destruction of part of the heart muscle. It often leaves sequelae because there is an irreversible loss of heart cells.

Myocardial infarction: 3 proteins to prevent heart failure

Some patients suffer from cardiac insufficiency after a heart attack. This chronic disease is characterized by an inability of the heart muscle to perform its normal role in driving blood throughout the body. Treatments and a healthy lifestyle can prevent exacerbation and limit the occurrence of decompensation episodes when patients require hospitalization.

After‘Health insurance, Heart attack is the most common cause of heart failure. Scientists have therefore worked to limit the risk of heart failure after a myocardial infarction. Their study has just been published in the journal Science Translational Medicine.

The researchers discovered three proteins that, given after a heart attack, could prevent the onset of heart failure. To do this, they used a technology called “FunSel,” which managed to identify these three human proteins among thousands. These are Chrdl1, Fam3c and Fam3b.

Protein administration after a heart attack

This is the first time that potential cardiac healing factors have been directly identified for their therapeutic potential“, explains Mauro Giacca, one of the authors of the study in a communicates. In fact, according to experiments conducted on mice in the laboratory, these three proteins would prevent heart damage after a heart attack and thus the risk of heart failure.

Any of the three proteins we identified can be administered immediately after a heart attack to minimize heart damage and thereby prevent heart failure. developed by Mauro Giacca. There hasn’t been a major breakthrough in this area for a long time, so we’re very excited about this discovery.

So far, the effectiveness of these three proteins has only been demonstrated in mice, but they will soon be tested on humans. “The potential of this therapy is extremely important and could revolutionize the treatment of patients at risk for heart failure.concludes Ajay Shah, Professor and Director of British Heart Foundation Center for Research Excellence at King’s College London. There is no effective preventive therapy for cardiac tissue deterioration after a [infarctus du myocarde]so this is a big step forward in this area.


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