A decade of discoveries ⋅ Inserm, From science to health

For nearly ten years, the FondaMental foundation has been following the largest cohort of patients with bipolar disorders ever formed. The goal: to identify the markers of the different clinical forms of these very heterogeneous disorders, and to analyze the trajectories of the disease in order to identify and correct the factors of poor prognosis.

An article to be found in Inserm magazine n°54

Without knowing it, everyone probably knows someone with bipolar disorder. One in 100 people, according to epidemiological studies, is indeed affected. It is the sixth leading cause of disability worldwide: patients are prone to manic phases – resulting in hyperactivity, euphoria, and other behavioral disorders that have a major impact on social life, professional and emotional – and to depressive phases. Unfortunately, bipolar disorders are associated with a reduction in life expectancy of 10 years due to the associated risks of suicidal behavior, and comorbidities somatic such as cardiovascular diseases.

Despite this bleak picture, research on bipolar disorder is lagging behind. It is to address this gap that the FACE-BD cohort (FondaMental Advanced Center of Expertise for Bipolar Disorder) was created about ten years ago by the FondaMental foundation. To date, it includes 4,422 people with this disorder. In a recent publication