DECRYPTION – A French team has developed a process for delivering anti-cancer products subcutaneously.
Have a small device implanted under the skin and a catheter connected to a large vein in the thorax; keep this device for several months, at the cost of some discomfort and risk of infection; keep a scar that will remind you of those difficult times… The use of an implantable port is necessary for the majority of chemotherapy, but this restrictive procedure is expensive and complicates the lives of patients and caregivers alike. What if we could simplify things?
A few oral chemotherapies exist, but this type of formulation in particular poses problems of bioavailability (the part of the active principle which actually reaches the blood network, very variable from one patient to another and in the same patient from one dose to ‘other).
As for subcutaneous injection, it has hitherto come up against the irritant and blistering properties, but also the hydrophobic properties of most anticancer molecules, properties that promote ulceration or even necrosis of the skin…